Patients with previous thyroid disease were excluded. METHOD: This was a cross-sectional study including 298 patients with epilepsy. This study aimed to determine the potential risk factors of low thyroid function in patients with epilepsy. Many studies have shown that AEDs have a negative influence on endocrine function including the thyroid gland, however the risk factors for the development of low thyroid function in these patients are unclear. PURPOSE: Patients with epilepsy are frequently required to take antiepileptic drugs (AEDs) for a long period of time. Wisselwerkingen tussen schildklierhormoon en andere medicijnen Deze studie heeft de mogelijke risicofactoren van een trage schildklierfunctie bij patiënten met epilepsie onderzocht.Įffects of antiepileptic drugs on thyroid hormone function in epilepsy patients Maar de kans om een trage schildklier te krijgen is onduidelijk bij deze epilepsiepatiënten. Veel studies hebben aangetoond dat AEDs een negatieve invloed hebben op de werking van de schildklier. Additionally, results showed that serious problem behavior is highly prevalent in adolescents with Down syndrome.Patiënten met epilepsie moeten vaak lange tijd anti-epilepsie geneesmiddelen (AEDs) gebruiken. In the fourth study, results showed that adolescents with Down syndrome remain dependent to a large degree and have serious difficulties in functioning socially. Children with Down syndrome and recurrent respiratory tract infections showed relatively more delayed development. The third study showed that eight-year-old children with Down syndrome have an average developmental delay of four years, more often have emotional and behavioral problems, and have a less favorable health-related quality of life (HRQoL) compared with children from the general population. Furthermore, Dutch children with Down syndrome have alarmingly high prevalence rates of overweight and obesity during childhood and adolescence. In the second study is observed that growth retardation in children with Down syndrome meanly occurs in three critical periods of growth, resulting in shorter final stature and smaller head circumference than the general Dutch population shows.
The first study showed that the number of live births of children with Down syndrome in the Netherlands remained stable over the period 1997-2007 on 14.6 per 10,000 births. Show more In this thesis, four studies on children and adolescents with Down syndrome are described.
Growth, development and social functioning of individuals with Down syndrome Doctoral Thesis In this thesis, four studies on children and adolescents with Down syndrome are described. Curriculum Vitae_List of publications_Afterword_Acknowledgements.Part 4 Social functioning and behavior at adolescence.
Part 3 Development and behaviour in childhood.
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